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Sicle Cell Anemia in African and Middle Eastern Decent

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I am reading that sickle-cell anemia is a disease that is genetically prevalent in populations of African and middle eastern decent. How is it that a parent can have the disease and not the offspring and vice versa?

Can you provide simple to understand websites for me to continue research on this topic?

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Hi

Sickle cell anemia is an autosomal recessive genetic disease that is found in people of African and Middle Eastern heritage. It is the result of a small change in the DNA that changes the amino acid sequence of the protein haemoglobin (for more details see http://radlinux1.usuf1.usuhs.mil/rad/home/cases/sickle.html). Haemoglobin is the oxygen carrying molecule found in red blood cells. It is mainly responsible for the overall shape of red blood cells, which are normally small and flattened, with an indent in the centre (like a filled ...

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