Why are RNA polymerases not able to correct base errors during replication or transcription

Discuss why RNA polymerases are not able to correct base errors during replication or transcription. Describe the biological consequences of the protein that may develop in this case.

Non-covalent interactions in proteins

Which non covalent interactions are most likely to be important in protein-protein interactions in aqueous environment? I think it is hydrogen bonding but not sure why What is the driving force for proteins that are embedded in lipid membranes? (i think it is the nonpolar groups of the proteins keep them embedded because th ...continues

Titration problem for alanine

How to do a titration curve from the following problem: 0.1 mol alanine adjusted to ph 0.5 with hcl, begin by adding 1.0M NAOH to the alanine solution. I know there will be two inflection points but I don't know how to calculate anything.

biochem problem set

how do you calculate the pH of a solution of lysine if the side chain amino group is 3/4 dissociated what is the isoelectric point of His For L-Ile, describe with drawings why it is 2S,3S what are the 6 atoms that are coplanar due to the resticted rotation about the peptide bond how many different tetrapeptide sequen ...continues

pH of glycine after addition of acid/base

If I had 1L of a 1.0M solution of glycine at the isoelectric pH (6.02) and I added 0.3 mol of HCL, what would be the new pH? What would be the pH if I added 0.3 mol of NaOH instead of the acid? my thoughts* I know that the Henderson-Hasselbalch equation should be used (pH=pk+log [conj base/conj.acid]), but I can only see this ...continues

hender/hasselbach problem

the E-amino group of lysine has a pka of 10.5 a) what fraction of these groups will be protonated in a dilute solution of lysine at pH9.5 b) at pH 11.0

Human Genome

I understand the use of processed food products required some adaptation on the human genome level. Animals do not consume sterile alcoholic beverages and milk is only consumed by the young. How did human populations adapt to alcohol consumption and how did they adapt to milk consumption in adult life?

genetics

Are all transcribed genes translated into proteins and why?

biochem

(See attached file for full problem description) --- For problems 6-8, assume standard conditions of pH 7 and 25C, unless otherwise stated, and assume equilibrium constants in which any [H+] and [H2O] terms have been incorporated into the constant, i.e., you don't have to use [H+] in any of the calculations. 6. Th ...continues

Amino acid problems

(See attached file for full problem description) --- 9. An organism of unknown origin produces a potent inhibitor of nerve conduction which you wish to sequence. Amino acid analysis shows the peptide's composition to be 5 Ala, 1 Lys, 1 Phe. Reaction of the intact peptide with phenylisothiocyanate (Edman's reagent) followed ...continues