Goldman equation
The question asks:
Calc. the membrane potential from Goldman equation using pNa/pK = 0.02 & the conc. of Na & K inside & outside the cell. Calc. the membrane potential using pNa/pK = 20. Compare these calculated values of membrane potential with the numbers from the simulation. Why does the membrane potential shift when pNa/pK moves from 0.02 to 20? Use [Na]i =12, [Na]o = 120, [K]i = 125, [K]o = 5.
==> I already calculated using the Goldman equation. I got -71.25 mV for pNa/pK = 0.02 and 47.49 mV for pNa/pK = 20. I said as the permeability ratio of Na and K increases, the potential is more positive. (Is it right?) Then I don't know how to explain the "why" question. Is it relate to depolarization and hyperpolarization? I don't know the relationship between the (+) or (-) potential and the permeability of Na and K. Please help.
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