Generation of Diversity

Explain the purpose (and briefly the method) of generating a TCR transgenic mouse ? Why TCR transgenic mice are often made on a rag-/- background ?

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Potential problems with transgenic mouse strains. - You have created 3 independent mouse strains carrying the same transgene by non-targeted transgenesis. All 3 strains have otherwise identical genetic backgrounds, yet all 3 have different phenotypes. ...
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