What is a theory (somatic mutation model) supposed to accomplish? What is the purpose of competing theories? When can you discard a theory? What constitutes "success?" These are obviously philosophical questions, and scientific philosophers have puzzled over them quite a bit. So my challenge to you this week is to address those ...continues
See attached file for full problem description. Table 1: Affinities of tg ARS antibodies It is possible to make transgenic (tg) mice whose B cells ___________________________________ express a tg heavy chain gene. An investigator recently Antibody Ka did an intriguing experiment to probe the basis for ___________________ ...continues
Professor Owen made an astute observation: In outbred cattle, dizygotic twins that share the same placenta occur occasionally. Indeed, if one examines peripheral blood samples from such twin pairs, each has blood cells derived from the other, indicating a shared circulatory systems in utero. Surprisingly, even though they are no ...continues
a): Specify the child’s problem in immunologic terms, and tell how it explains his symptoms. b). Speculate BRIEFLY on the underlying mechanism of the child’s disease, AND its likely mode of transmission. c). What would you do to treat this child? What potential problems do you foresee with your treatment? See attach ...continues
Immunology experiment telling what types of molecules should be present.
An experiment that used syngeneic mice that had been immunized with ovalbumin. Experimental group: Dendritic cells were fed ovalbumin four hours prior to mixing splenic CD3+ and CD4+ mixed together (control group splenic CD3+ and CD4+ only). An hour after the cells had been mixed together they were lysed and immunoprecipitati ...continues
1) Describe how the mammalian immune system responds to (i) a laceration, such as an injury from falling on a barbed-wire fence, and (ii) a viral infection. 2) Explain how the flu vaccination works and why it has a fairly low success rate.
MHC restriction and self-tolerance
What is the difference between MHC restriction and self-tolerance? How would apoptosis explain positive selection?
How do CTLs utilize Fas? Could Fas be utilized to eliminate T cells?
How do CTLs utilize Fas? Could Fas be utilized to eliminate T cells?
How would DNA translocation produce cancer?
How would DNA translocation produce cancer?
There are mechanisms by which tumors destroy immune surveillance. How would you design cancer therapies to target these methods of evading the immune system.
