4. An investigator performed cytofluorimetric (FACS) analyses of a mouse
strain called C.B20 and a spontaneously arising point mutant that arose
in the same strain called "C.B20 scid." Splenocytes from each strain
were stained with anti-IgM (green) and anti-CD3 (red), then analyzed.
The proportion of cells falling into each phenotypic category defined by
these markers were then assessed.
Â
STRAIN IgM-CD3- IgM+CD3- IgM-CD3+
C.B20 5 60 35
C.B20 scid 98 0 0
Â
The table below shows the results from all possible donor-recipient
combinations of skin grafts between C.B20, C.B20 scid and another,
genetically disparate strain called C57BL. Each kind of graft was done
on ten mice.
Â
Proportion of grafts surviving after 30 days
DONOR RECIPIENT
 C.B20 C.B20 scid C57BL
C.B20 100% 100% 0%
C.B20 scid 100 100 0
C57BL 0 100 100
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From the first table, what do you conclude about the scid mutation?
Â
From the second table, what do you conclude about the mechanism of graft
rejection?
Biology Homework Solutions
#122241
q4 need concise answers
4. An investigator performed cytofluorimetric (FACS) analyses of a mouse strain called C.B20 and a spontaneously arising point mutant that arose in the same strain called "C.B20 scid." Splenocytes from each strain were stained with anti-IgM (green) and anti-CD3 (red), then analyzed. The proportion of cells falling into each phenotypic category defined by these markers were then assessed.
*(See Attached)
The table below shows the results from all possible donor-recipient combinations of skin grafts between C.B20, C.B20 scid and another, genetically disparate strain called C57BL. Each kind of graft was done on ten mice.
*(See Attached)
• From the first table, what do you conclude about the scid mutation?
• From the second table, what do you conclude about the mechanism of graft rejection?
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